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By Abelson J.N., Simon M.I., Phillips I.M.

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Sobel, Proc. Natl. Acad. Sci. A. 93(7), 2909 (1996). 18 M. J. McCluskie, Y. Chu, J. L. Xia, J. Jessee, G. Gebyehu, and H. L. Davis, Antisense Nucleic Acid Drug. Dev. 8(5), 401 (1998). 36 ANTISENSERECEPTORTARGETS [3] Generally, plasmid D N A is considered safer to use than viral vectors, but expression is usually less efficient and shorter lasting. Some improvement has been shown by using different carriers and/or complexing agents, such as liposomes, polyvinylpyrrolidone, or starburst dendrimers.

Jaffe, N. T. Eissa, and C. Daniel, Nature Genet. 1, 42 (1994). 34 B. Quantin, L. D. Perricaudet, S. -L. Mandel, Proc. Natl. Acad. Sci. A. 89, 2581 (1992). 35 G. Le Gal La Salle, J. J. Robert, S. Berrard, V. Ridoux, L. D. Stratford-Perricaudet, M. Perricaudet, and J. Mallet, Science 259, 988 (1993). 36 A. Novials, J. C. Jimenez-Chillaron, C. Franco, R. Casamitjana, R. Gomis, and A. M. Gomez-Foix, Pancreas 17(2), 182 (1998). 37 D. tu, H. Yang, and M. K. Raizada, Am. J. Physiol. 274(2 Pt. 2), H719 (1998).

Acad. Sci. A. 89, 2581 (1992). 35 G. Le Gal La Salle, J. J. Robert, S. Berrard, V. Ridoux, L. D. Stratford-Perricaudet, M. Perricaudet, and J. Mallet, Science 259, 988 (1993). 36 A. Novials, J. C. Jimenez-Chillaron, C. Franco, R. Casamitjana, R. Gomis, and A. M. Gomez-Foix, Pancreas 17(2), 182 (1998). 37 D. tu, H. Yang, and M. K. Raizada, Am. J. Physiol. 274(2 Pt. 2), H719 (1998). 38j. M. Bergelson, J. A. Cunningham, G. Drognett, E. A. Kurt-Jones, A. Krithivas, J. S. Hong, M. S. Horwitz, R. L. Crowell, and R.

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Antisense Technology: Applications Part B by Abelson J.N., Simon M.I., Phillips I.M.


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