By Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)
Aminopeptidases in Biology and Disease presents a complete overview of the rising function of aminopeptidases in a variety of organic tactics and illness events. tactics as varied as angiogenesis, antigen presentation, neuropeptide and hormone processing, being pregnant and copy, protein turnover, reminiscence, irritation, tumour development, melanoma and metastasis, blood strain and high blood pressure all seriously contain a number of aminopeptidases. the person chapters were written by means of specialists within the box who've supplied certain debts of the imperative roles performed through a number of aminopeptidases in biology and disease.
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Extra info for Aminopeptidases in Biology and Disease
1986, Inactivation and metabolism ofneuropeptides. Ann. Rev. Neurosci. 9: 415-434. , 1988, Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopept idases. J. Neurochem . 51: 1552-1559. , 1994, Increased fearfulness ofFyn tyrosine kinase deficient mice. Brain Res. Mol. Brain Res. 27: 179-182. , 1994, Internalization and nuclear localization of peptide hormones. Biochem. Pharmacol. 47: 63-76. , 1994, Effect of ubenimex on the proliferation and differentiation ofU937 human histiocytic lymphoma cells.
Thus, TNP-470 and ovalicin have a high specificity for MetAP2. Crystal structure studies of human MetAP2 complexed with fumagillin revealed that the imidazole nitrogen (NE2) of the conserved catalytic residue His 231 covalently attaches to the C3 ring epoxide group of fumagillin (Liu et al. 1998). These studies are further supported by the findings that the substitution of His231 with Asn in hMetAP2 precludes the covalent attachment of fumagillin to hMetAP2 and that the C3 ring epoxide group is required for EC growth inhibition by the fumagillin class of angiogenesis inhibitors (Griffith et al.
2001, Augmentation of death-ligand induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines. Int. J. Cancer 94: 485-491. , 1994, Trimming of antigenic peptides in an early secretory compartment. J. Exp. Med. 180: 2389-2394. , 2000, Two new proteases in the MHC class I processing pathway. Nat. Immunol. 1: 413-418. , 1998, Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities.
Aminopeptidases in Biology and Disease by Michael W. Thompson, Louis B. Hersh (auth.), Nigel M. Hooper, Uwe Lendeckel (eds.)