By Sir Leslie Fowden (auth.), Gert Lubec, Gerald A. Rosenthal (eds.)
The research of amino acids is of primary curiosity to scientists from many diversified fields. This curiosity derives from their function because the simple parts of proteins as well as their skill to function construction blocks for the creation of many sessions of secondary metabolites. they could help the biosynthesis of a myriad of ordinary items together with non-protein amino acids, cyanogenic glycosides, pharmacologically lively alkaloids, yes phenols, purines and pyrimidines, nucleic acids. condensed tannins, lignins and different metabolites.
The contributions contained during this paintings originate from the 1st overseas Congress in Amino Acid study. This number of papers will entice researchers within the fields of biochemistry, vascular and cellphone biology, body structure, pharmacology, endocrinology and scientific medication.
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Extra info for Amino Acids: Chemistry, Biology and Medicine
15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. Widmer U, Heimgartner H and Schmid H (1978) Helv. Chim. Acta 61: 815. Hoet P (1975) Dissertation Universite Catholique de Louvain. Heimgartner H (1981) Israel J. Chern. 21: 151. Heimgartner H (1986) Israel J. Chern. 27: 3. Ametamey SM, Hollenstein R and Heimgartner H (1988) Helv. Chim. Acta 71: 521. Chaloupka S, Vittorelli P, Heimgartner H, Schmid H, Link H, Bernauer K and Oberhiinsli WE (1977) Helv.
L. sativus is the agronomically most important species of the genus. Partly because of its drought tolerance, it is cultivated on several million hectare in Asia and Africa. Selection of low toxin varieties is being pursued on a large scale in several institutes in different parts of the world . Together with other nonprotein amino acids, ODAP was found to be present in the chloroplasts, the potential site of biosynthesis . Isoxazolin-5-one derivatives Two natural compounds present in seedlings of Lathyrus species and containing the heterocyclic isoxazolinone ring are toxic to animals: 2-(3-amino-3-carboxy- 23 propyl)-isoxazolin-5-one (compound VI, Scheme 1) can be hydrolysed or photolysed with the formation of DABA .
Odoratus has been described as only osteolathyritic. However, when feeding freeze-dried seedlings to day-old chicks they develop the symptoms of both neurolathyrism and osteolathyrism, obviously due to the presence of VI in a concentration of 3% of the dry weight of the seedlings. Also L. sativus that is described as only neurotoxic, contains VIII in the seedling stage. The presence of small concentrations of VIII in the dry seeds of L. sativus may be responsible for the minor skeletal lesions observed in older lathyrism patients .
Amino Acids: Chemistry, Biology and Medicine by Sir Leslie Fowden (auth.), Gert Lubec, Gerald A. Rosenthal (eds.)