By Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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9a]. The t(8;14) has also been observed in nonendemic Burkitt tumors from America, Europe, and Japan. Thus, there is no doubt that the t(8;14) is a highly characteristic chromosome anomaly in Burkitt 38 Michelle M. Le Beau and Janet D. Rowley tumors. This translocation was identified in Burkitt tumors that lack any markers positive for EBV, as well as in EBV-positive tumors. , 1983). As additional Burkitt tumors were examined, it became apparent that at least two other, related translocations could occur.
1983), and only a few of their pertinent conclusions will be considered here. First, although the breakpoint in the Ig heavy chain gene is within a relatively restricted DNA segment, usually the constant region, the break adjacent to c-myc may be within the first intron of the gene in some cases, but may be at some distance in others. Second, in the t(8;14), the break is in the 5' region of c-myc, whereas it is in the 3' region in the t(2;8) and t(8;22). In the variant translocations, then, c-myc is not translocated to a chromosome containing the immunoglobulin genes (chromosome 2 or 22); rather, c-myc remains on 8q and the immunoglobulin genes are relocated.
Isolation and analysis of these segments of DNA have a high research priority. The evidence in Burkitt lymphoma is exciting and clearly points the way for future research in this area. The loci for the immunoglobulin genes are on the three chromosomes, other than chromosome 8, that are involved in translocations in Burkitt lymphoma. Thus, the locus for the heavy chain complex is on chromosome 14, that for the K light chain is on chromosome 2, and that for the A chain is on chromosome 22. Moreover, with the use of chromosome hybridization in situ, the K light chain genes have been mapped to the short arm of chromosome Chapter 1: Chromosomal Abnormalities in Leukemia and Lymphoma 41 2 (band 2pI2-13), the heavy chain gene has been mapped to 14q32, and the A light chain gene has been mapped to 22qll [reviewed in Rowley (1982), ar-Rushdi et al.
Advances in Human Genetics 15 by Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)