M. Demerec (Ed.)'s Advances in Genetics, Vol. 1 PDF

By M. Demerec (Ed.)

ISBN-10: 0120176017

ISBN-13: 9780120176014

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20. Petersdorf EW, Hansen JA, Martin PJ, et al. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med 2001; 345:1794–1800. 21. Petersdorf EW, Anasetti C, Martin PJ, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood 2004; 104:2976–2980. Chapter 2 Stem Cell Transplantation for Hematologic Malignancies 22. Anasetti C, Hansen JA. Effect of HLA incompatibility in marrow transplantation from unrelated and HLA-mismatched related donors.

102. Lambert JF et al. H2-mismatched transplantation with repetitive cell infusions and CD40 ligand antibody infusions without myeloablation. Br J Haematol 119, 155–63 (2002). Chapter 2 Stem Cell Transplantation for Hematologic Malignancies Effie W. Petersdorf 1. Introduction Histocompatibility in transplantation is governed by the products of the human leucocyte antigen (HLA) genes encoded within the major histocompatibility complex (MHC) on chromosome 6p21. HLA antigens define tissue type and are inherited en bloc in classical Mendelian fashion.

HLA Disparity and GVL after Unrelated HCT Most of the published HLA studies have focused on quantifying risks associated with HLA mismatching and graft failure, GVHD and mortality. One potential benefit of HLA disparity is lower disease recurrence arising from graft-versusleukemia in patients with clinical GVHD [80]. HLA-DP mismatching has a lower risk of disease recurrence, particularly in patients with lymphoid malignancies [72]. GVL effects may also be contributed by non-HLA loci; lower post-transplant relapse has been observed after non-myeloablative unrelated, compared to related donor HCT, and likely reflect the impact of undetected genetic disparity among unrelated individuals who are HLA matched [64].

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Advances in Genetics, Vol. 1 by M. Demerec (Ed.)


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